Electrospinning (e-spinning) devices and electrospun (e-spun) ultrathin fibers have shown promising applications in various fields. However, the poor portability of conventional e-spinning devices limits some potential applications especially in the case without a plug (electricity supply). Consequently, great efforts have been made to modify e-spinning setups with good portability. In this article, a solar cell and a hand generator-powered portable e-spinning (SHPE) setup with good flexibility is introduced, which can be used outdoors without a plug. The SHPE device shows good spinning efficacy both in solution and melt e-spinning processes for a wide range of polymers. Moreover, the designed SHPE apparatus demonstrates potential application in wound dressing by in situ e-spinning fibers onto human skin directly.