Phase change nanofibers based on polyamide 6 and polyethylene glycol, in which polyethylene glycol acted as a model phase change material and polyamide 6 acted as a supporting material, were successfully prepared via electrospinning. Morphology, compatibility, thermal stability, thermo-regulated performance and physical properties of the polyamide 6/polyethylene glycol thermo-regulated nanofibers were studied. Morphology observation indicates that the addition of polyethylene glycol can improve the spinnability of the nanofibers, and polyamide 6 has a good compatibility with polyethylene glycol. Fourier transform infrared spectrometer characterization results show that polyethylene glycol is well added into polyamide 6 nanofibers, and hydrogen bonding interactions exist between polyamide 6 and polyethylene glycol. Differential scanning calorimetry and heating (cooling) experiment analyses show that the electrospinning polyamide 6/polyethylene glycol blended nanofiber has effective thermo-regulated properties. Mechanical properties experiments show that tensile strength of polyamide 6/polyethylene glycol composite nanofibers decreases with the increasing of polyethylene glycol content in the nanofibers.