Poly(ethylene glycol -co- DL-lactide) (PELA) is a biodegradable polymer, which has attracted considerable interest in the area of drug release due to its potential as drug carrier. Drug-loaded electrospun PELA fibers tend to be a promising candidate for local chemotherapy application in the future. In this study, curcumin was encapsulated into PELA fibers (Cur@PELA) for drug delivery via electrospinning. It was found that the shrinkage ratio, porosity, water absorption and water contact angle of Cur@PELA fiber membrane could be changed by heat treatment with different heating temperature (45 degrees C, 50 degrees C) and heating time (5 min, 10 min, 20 min). Moreover, the release rate of curcumin from Cur@PELA fibers was influenced by the porosity, water absorption and water contact angle of the drug-loaded membrane. Heat treatment is thought to be a novel method to control release of drug from electrospun PELA fibers.