In this work poly(3,4-ethylenedioxythiophene) (PEDOT) coated SnO2-Fe2O3 continuous nanotubes with a uniform core-shell structure have been demonstrated for rapid sensitive detection of iodide ions. The SnO2-Fe2O3 nanotubes were firstly fabricated via an electrospinning technique and following calcination process. An in situ polymerization approach was then performed to coat a uniform PEDOT shell on the surface of as-prepared SnO2-Fe2O3 nanotubes by vapor phase polymerization, using Fe2O3 on the surface of nanotubes as an oxidant in an acidic condition. The resultant PEDOT@SnO2-Fe2O3 core-shell nanotubes exhibit a fast response time (similar to 4 s) toward iodide ion detection and a linear current response ranging from 10 to 100 mu M, with a detection limit of 1.5 mu M and sensitivity of 70 mu A/mM/cm(2). The facile fabrication process and high sensing performance of this study can promote a wide range of potential applications in human health monitoring and biosensing systems.