Curcumin/Hydroxypropyl-beta-Cyclodextrin (HP-beta-CyD) and Curcumin/Hydroxypropyl-gamma-Cyclodextrin (HP-gamma-CyD) inclusion complex nanofibrous webs were produced using electrospinning technique for the purpose of orally fast-dissolving antioxidant food supplement. Curcumin was totally preserved without any loss during the electrospinning process. The aqueous solutions of curcumin/HP-beta-CyD and curcumin/HP-gamma-CyD were yielded uniform fiber morphology with similar to 200 nm and similar to 900 nm average fiber diameter, respectively. Both Curcumin/CyD webs were produced in the form of free-standing and flexible character. Curcumin is a natural bioactive compound with poor water-solubility, however, the phase solubility test and dissolution/disintegration tests (water and artificial saliva) revealed that the water-solubility of curcumin was prominently improved by inclusion complexation with CyD. The antioxidant effect of curcumin in Curcumin/CyD webs was also enhanced due to higher solubility of curcumin by CyD inclusion complex. The results showed that HP-gamma-CyD is significantly more effective than HP-beta-CyD in order to enhance the solubility and antioxidant property of curcumin in Curcumin/CyD webs.